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Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular component: cytosol

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF01851
Domain description: Proteasome/cyclosome repeat
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 1
  2. 26S proteasome non-ATPase regulatory subunit 2
The deposited structure of PDB entry 5vhh contains 3 copies of Pfam domain PF01851 (Proteasome/cyclosome repeat) in 26S proteasome non-ATPase regulatory subunit 1. Showing 3 copies in chain G [auth U].
The deposited structure of PDB entry 5vhh contains 2 copies of Pfam domain PF01851 (Proteasome/cyclosome repeat) in 26S proteasome non-ATPase regulatory subunit 2. Showing 2 copies in chain S [auth f].

PF17862
Domain description: AAA+ lid domain
Occurring in:
  1. 26S proteasome regulatory subunit 7
  2. 26S proteasome regulatory subunit 4
  3. 26S proteasome regulatory subunit 8
  4. 26S proteasome regulatory subunit 6B
  5. 26S proteasome regulatory subunit 10B
  6. 26S proteasome regulatory subunit 6A
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF17862 (AAA+ lid domain) in 26S proteasome regulatory subunit 7. Showing 1 copy in chain A.
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF17862 (AAA+ lid domain) in 26S proteasome regulatory subunit 4. Showing 1 copy in chain B.
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF17862 (AAA+ lid domain) in 26S proteasome regulatory subunit 8. Showing 1 copy in chain C.
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF17862 (AAA+ lid domain) in 26S proteasome regulatory subunit 6B. Showing 1 copy in chain D.
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF17862 (AAA+ lid domain) in 26S proteasome regulatory subunit 10B. Showing 1 copy in chain E.
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF17862 (AAA+ lid domain) in 26S proteasome regulatory subunit 6A. Showing 1 copy in chain F.

PF00004
Domain description: ATPase family associated with various cellular activities (AAA)
Occurring in:
  1. 26S proteasome regulatory subunit 7
  2. 26S proteasome regulatory subunit 4
  3. 26S proteasome regulatory subunit 8
  4. 26S proteasome regulatory subunit 6B
  5. 26S proteasome regulatory subunit 10B
  6. 26S proteasome regulatory subunit 6A
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in 26S proteasome regulatory subunit 7. Showing 1 copy in chain A.
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in 26S proteasome regulatory subunit 4. Showing 1 copy in chain B.
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in 26S proteasome regulatory subunit 8. Showing 1 copy in chain C.
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in 26S proteasome regulatory subunit 6B. Showing 1 copy in chain D.
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in 26S proteasome regulatory subunit 10B. Showing 1 copy in chain E.
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in 26S proteasome regulatory subunit 6A. Showing 1 copy in chain F.

PF01399
Domain description: PCI domain
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 3
  2. 26S proteasome non-ATPase regulatory subunit 12
  3. 26S proteasome non-ATPase regulatory subunit 11
  4. 26S proteasome non-ATPase regulatory subunit 6
  5. 26S proteasome non-ATPase regulatory subunit 13
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF01399 (PCI domain) in 26S proteasome non-ATPase regulatory subunit 3. Showing 1 copy in chain H [auth V].
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF01399 (PCI domain) in 26S proteasome non-ATPase regulatory subunit 12. Showing 1 copy in chain I [auth W].
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF01399 (PCI domain) in 26S proteasome non-ATPase regulatory subunit 11. Showing 1 copy in chain J [auth X].
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF01399 (PCI domain) in 26S proteasome non-ATPase regulatory subunit 6. Showing 1 copy in chain K [auth Y].
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF01399 (PCI domain) in 26S proteasome non-ATPase regulatory subunit 13. Showing 1 copy in chain M [auth a].

PF16450
Domain description: Proteasomal ATPase OB C-terminal domain
Occurring in:
  1. 26S proteasome regulatory subunit 4
  2. 26S proteasome regulatory subunit 8
  3. 26S proteasome regulatory subunit 6B
  4. 26S proteasome regulatory subunit 10B
  5. 26S proteasome regulatory subunit 6A
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF16450 (Proteasomal ATPase OB C-terminal domain) in 26S proteasome regulatory subunit 4. Showing 1 copy in chain B.
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF16450 (Proteasomal ATPase OB C-terminal domain) in 26S proteasome regulatory subunit 8. Showing 1 copy in chain C.
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF16450 (Proteasomal ATPase OB C-terminal domain) in 26S proteasome regulatory subunit 6B. Showing 1 copy in chain D.
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF16450 (Proteasomal ATPase OB C-terminal domain) in 26S proteasome regulatory subunit 10B. Showing 1 copy in chain E.
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF16450 (Proteasomal ATPase OB C-terminal domain) in 26S proteasome regulatory subunit 6A. Showing 1 copy in chain F.

PF12796
Domain description: Ankyrin repeats (3 copies)
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 10
The deposited structure of PDB entry 5vhh contains 4 copies of Pfam domain PF12796 (Ankyrin repeats (3 copies)) in 26S proteasome non-ATPase regulatory subunit 10. Showing 4 copies in chain R [auth G].

PF01398
Domain description: JAB1/Mov34/MPN/PAD-1 ubiquitin protease
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 7
  2. 26S proteasome non-ATPase regulatory subunit 14
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF01398 (JAB1/Mov34/MPN/PAD-1 ubiquitin protease) in 26S proteasome non-ATPase regulatory subunit 7. Showing 1 copy in chain L [auth Z].
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF01398 (JAB1/Mov34/MPN/PAD-1 ubiquitin protease) in 26S proteasome non-ATPase regulatory subunit 14. Showing 1 copy in chain O [auth c].

PF17781
Domain description: RPN1 N-terminal domain
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 2
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF17781 (RPN1 N-terminal domain) in 26S proteasome non-ATPase regulatory subunit 2. Showing 1 copy in chain S [auth f].

PF05160
Domain description: DSS1/SEM1 family
Occurring in:
  1. 26S proteasome complex subunit SEM1
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF05160 (DSS1/SEM1 family) in 26S proteasome complex subunit SEM1. Showing 1 copy in chain Q [auth e].

PF10075
Domain description: CSN8/PSMD8/EIF3K family
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 8
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF10075 (CSN8/PSMD8/EIF3K family) in 26S proteasome non-ATPase regulatory subunit 8. Showing 1 copy in chain P [auth d].

PF13519
Domain description: von Willebrand factor type A domain
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 4
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF13519 (von Willebrand factor type A domain) in 26S proteasome non-ATPase regulatory subunit 4. Showing 1 copy in chain N [auth b].

PF22037
Domain description: PSD13 N-terminal repeats
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 13

PF13012
Domain description: Maintenance of mitochondrial structure and function
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 7
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF13012 (Maintenance of mitochondrial structure and function) in 26S proteasome non-ATPase regulatory subunit 7. Showing 1 copy in chain L [auth Z].
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF13012 (Maintenance of mitochondrial structure and function) in 26S proteasome non-ATPase regulatory subunit 14. Showing 1 copy in chain O [auth c].

PF21154
Domain description: 26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 6

PF10602
Domain description: 26S proteasome subunit RPN7
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 6
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF10602 (26S proteasome subunit RPN7) in 26S proteasome non-ATPase regulatory subunit 6. Showing 1 copy in chain K [auth Y].

PF18503
Domain description: 26S proteasome subunit RPN6 C-terminal helix domain
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 11
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF18503 (26S proteasome subunit RPN6 C-terminal helix domain) in 26S proteasome non-ATPase regulatory subunit 11. Showing 1 copy in chain J [auth X].

PF18055
Domain description: 26S proteasome regulatory subunit RPN6 N-terminal domain
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 11
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF18055 (26S proteasome regulatory subunit RPN6 N-terminal domain) in 26S proteasome non-ATPase regulatory subunit 11. Showing 1 copy in chain J [auth X].

PF18098
Domain description: 26S proteasome regulatory subunit RPN5 C-terminal domain
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 12
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF18098 (26S proteasome regulatory subunit RPN5 C-terminal domain) in 26S proteasome non-ATPase regulatory subunit 12. Showing 1 copy in chain I [auth W].

PF22241
Domain description: PSMD12/CSN4, N-terminal
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 12

PF08375
Domain description: Proteasome regulatory subunit C-terminal
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 3
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF08375 (Proteasome regulatory subunit C-terminal) in 26S proteasome non-ATPase regulatory subunit 3. Showing 1 copy in chain H [auth V].

PF18004
Domain description: 26S proteasome regulatory subunit RPN2 C-terminal domain
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 1
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF18004 (26S proteasome regulatory subunit RPN2 C-terminal domain) in 26S proteasome non-ATPase regulatory subunit 1. Showing 1 copy in chain G [auth U].

PF13646
Domain description: HEAT repeats
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 1
The deposited structure of PDB entry 5vhh contains 1 copy of Pfam domain PF13646 (HEAT repeats) in 26S proteasome non-ATPase regulatory subunit 1. Showing 1 copy in chain G [auth U].

PF21505
Domain description: 26S proteasome subunit RPN2, N-terminal domain
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 1

PF21236
Domain description: 26S proteasome regulatory subunit 7, OB domain
Occurring in:
  1. 26S proteasome regulatory subunit 7

InterPro InterPro annotations
IPR000717
Domain description: Proteasome component (PCI) domain
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 3
  2. 26S proteasome non-ATPase regulatory subunit 12
  3. 26S proteasome non-ATPase regulatory subunit 11
  4. 26S proteasome non-ATPase regulatory subunit 6
  5. 26S proteasome non-ATPase regulatory subunit 13
  6. 26S proteasome non-ATPase regulatory subunit 8
IPR002110
Domain description: Ankyrin repeat
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 10
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. 26S proteasome regulatory subunit 7
  2. 26S proteasome regulatory subunit 4
  3. 26S proteasome regulatory subunit 8
  4. 26S proteasome regulatory subunit 6B
  5. 26S proteasome regulatory subunit 10B
  6. 26S proteasome regulatory subunit 6A
IPR041569
Domain description: AAA ATPase, AAA+ lid domain
Occurring in:
  1. 26S proteasome regulatory subunit 7
  2. 26S proteasome regulatory subunit 4
  3. 26S proteasome regulatory subunit 8
  4. 26S proteasome regulatory subunit 6B
  5. 26S proteasome regulatory subunit 10B
  6. 26S proteasome regulatory subunit 6A
IPR003960
Domain description: ATPase, AAA-type, conserved site
Occurring in:
  1. 26S proteasome regulatory subunit 7
  2. 26S proteasome regulatory subunit 4
  3. 26S proteasome regulatory subunit 8
  4. 26S proteasome regulatory subunit 6B
  5. 26S proteasome regulatory subunit 10B
  6. 26S proteasome regulatory subunit 6A
IPR003959
Domain description: ATPase, AAA-type, core
Occurring in:
  1. 26S proteasome regulatory subunit 7
  2. 26S proteasome regulatory subunit 4
  3. 26S proteasome regulatory subunit 8
  4. 26S proteasome regulatory subunit 6B
  5. 26S proteasome regulatory subunit 10B
  6. 26S proteasome regulatory subunit 6A
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. 26S proteasome regulatory subunit 7
  2. 26S proteasome regulatory subunit 4
  3. 26S proteasome regulatory subunit 8
  4. 26S proteasome regulatory subunit 6B
  5. 26S proteasome regulatory subunit 10B
  6. 26S proteasome regulatory subunit 6A
IPR012340
Domain description: Nucleic acid-binding, OB-fold
Occurring in:
  1. 26S proteasome regulatory subunit 7
  2. 26S proteasome regulatory subunit 4
  3. 26S proteasome regulatory subunit 8
  4. 26S proteasome regulatory subunit 6B
  5. 26S proteasome regulatory subunit 10B
  6. 26S proteasome regulatory subunit 6A
IPR036390
Domain description: Winged helix DNA-binding domain superfamily
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 3
  2. 26S proteasome non-ATPase regulatory subunit 12
  3. 26S proteasome non-ATPase regulatory subunit 11
  4. 26S proteasome non-ATPase regulatory subunit 6
  5. 26S proteasome non-ATPase regulatory subunit 13
IPR002015
Domain description: Proteasome/cyclosome repeat
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 1
  2. 26S proteasome non-ATPase regulatory subunit 2
IPR032501
Domain description: Proteasomal ATPase, second OB domain
Occurring in:
  1. 26S proteasome regulatory subunit 4
  2. 26S proteasome regulatory subunit 8
  3. 26S proteasome regulatory subunit 6B
  4. 26S proteasome regulatory subunit 10B
  5. 26S proteasome regulatory subunit 6A
IPR000555
Domain description: JAB1/MPN/MOV34 metalloenzyme domain
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 7
  2. 26S proteasome non-ATPase regulatory subunit 14
IPR007834
Domain description: DSS1/SEM1
Occurring in:
  1. 26S proteasome complex subunit SEM1
IPR002035
Domain description: von Willebrand factor, type A
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 4
IPR011990
Domain description: Tetratricopeptide-like helical domain superfamily
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 3
  2. 26S proteasome non-ATPase regulatory subunit 11
  3. 26S proteasome non-ATPase regulatory subunit 6
IPR036465
Domain description: von Willebrand factor A-like domain superfamily
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 4
IPR024969
Domain description: EIF3F/CSN6-like, C-terminal
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 7
  2. 26S proteasome non-ATPase regulatory subunit 14
IPR037518
Domain description: MPN domain
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 7
  2. 26S proteasome non-ATPase regulatory subunit 14
IPR011989
Domain description: Armadillo-like helical
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 1
  2. 26S proteasome non-ATPase regulatory subunit 2
IPR016024
Domain description: Armadillo-type fold
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 1
  2. 26S proteasome non-ATPase regulatory subunit 2
IPR036770
Domain description: Ankyrin repeat-containing domain superfamily
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 10
IPR040892
Domain description: RPN1, N-terminal
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 2
IPR016643
Domain description: 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 2
IPR033464
Domain description: CSN8/PSMD8/EIF3K
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 8
IPR006746
Domain description: 26S proteasome non-ATPase regulatory subunit Rpn12
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 8
IPR027040
Domain description: 26S proteasome non-ATPase regulatory subunit 4
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 4
IPR035298
Domain description: 26S Proteasome non-ATPase regulatory subunit 13
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 13
IPR033858
Domain description: 26S Proteasome non-ATPase regulatory subunit 7/8
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 7
IPR045135
Domain description: 26S proteasome regulatory subunit Rpn7, N-terminal
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 6
IPR019585
Domain description: 26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 6
IPR040780
Domain description: 6S proteasome subunit Rpn6, C-terminal helix domain
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 11
IPR040773
Domain description: 26S proteasome regulatory subunit Rpn6, N-terminal
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 11
IPR040896
Domain description: 26S proteasome regulatory subunit RPN5, C-terminal domain
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 12
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 12
IPR040134
Domain description: 26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 12
IPR013586
Domain description: 26S proteasome regulatory subunit, C-terminal
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 3
IPR040623
Domain description: 26S proteasome regulatory subunit RPN2, C-terminal
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 1
IPR016642
Domain description: 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit
Occurring in:
  1. 26S proteasome non-ATPase regulatory subunit 1

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