GO terms
Biochemical function:
Biological process:
- proteasome-mediated ubiquitin-dependent protein catabolic process
- regulation of protein catabolic process
- negative regulation of release of cytochrome c from mitochondria
- protein localization to plasma membrane
- proteasome regulatory particle assembly
- positive regulation of cyclin-dependent protein serine/threonine kinase activity
- negative regulation of DNA damage response, signal transduction by p53 class mediator
- negative regulation of MAPK cascade
- negative regulation of apoptotic process
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of NF-kappaB transcription factor activity
- positive regulation of protein ubiquitination
- positive regulation of cell growth
- cytoplasmic sequestering of NF-kappaB
- apoptotic process
- regulation of transcription by RNA polymerase II
- negative regulation of transcription by RNA polymerase II
Cellular component:
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 5vhr contains 1 copy of Pfam domain PF17862 (AAA+ lid domain) in 26S proteasome regulatory subunit 7. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/5vhr_2_A_Pfam_PF17862_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5vhr</span> contains 1 copy of Pfam domain <span class='highlight'>PF17862 (AAA+ lid domain)</span> in <span class='highlight'>26S proteasome regulatory subunit 7</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
![The deposited structure of PDB entry 5vhr contains 1 copy of Pfam domain PF17862 (AAA+ lid domain) in 26S proteasome regulatory subunit 4. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/5vhr_3_B_Pfam_PF17862_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5vhr</span> contains 1 copy of Pfam domain <span class='highlight'>PF17862 (AAA+ lid domain)</span> in <span class='highlight'>26S proteasome regulatory subunit 4</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>.")
![The deposited structure of PDB entry 5vhr contains 1 copy of Pfam domain PF17862 (AAA+ lid domain) in 26S proteasome regulatory subunit 8. Showing 1 copy in chain G [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/5vhr_7_C_Pfam_PF17862_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5vhr</span> contains 1 copy of Pfam domain <span class='highlight'>PF17862 (AAA+ lid domain)</span> in <span class='highlight'>26S proteasome regulatory subunit 8</span>. Showing 1 copy in chain <span class='highlight'>G [auth C]</span>.")
PF00004
Domain description:
ATPase family associated with various cellular activities (AAA)
Occurring in:
Occurring in:
![The deposited structure of PDB entry 5vhr contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in 26S proteasome regulatory subunit 7. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/5vhr_2_A_Pfam_PF00004_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5vhr</span> contains 1 copy of Pfam domain <span class='highlight'>PF00004 (ATPase family associated with various cellular activities (AAA))</span> in <span class='highlight'>26S proteasome regulatory subunit 7</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
![The deposited structure of PDB entry 5vhr contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in 26S proteasome regulatory subunit 4. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/5vhr_3_B_Pfam_PF00004_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5vhr</span> contains 1 copy of Pfam domain <span class='highlight'>PF00004 (ATPase family associated with various cellular activities (AAA))</span> in <span class='highlight'>26S proteasome regulatory subunit 4</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>.")
![The deposited structure of PDB entry 5vhr contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in 26S proteasome regulatory subunit 8. Showing 1 copy in chain G [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/5vhr_7_C_Pfam_PF00004_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5vhr</span> contains 1 copy of Pfam domain <span class='highlight'>PF00004 (ATPase family associated with various cellular activities (AAA))</span> in <span class='highlight'>26S proteasome regulatory subunit 8</span>. Showing 1 copy in chain <span class='highlight'>G [auth C]</span>.")
![The deposited structure of PDB entry 5vhr contains 4 copies of Pfam domain PF12796 (Ankyrin repeats (3 copies)) in 26S proteasome non-ATPase regulatory subunit 10. Showing 4 copies in chain A [auth G].](https://www.ebi.ac.uk/pdbe/static/entry/5vhr_1_G_Pfam_PF12796_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5vhr</span> contains 4 copies of Pfam domain <span class='highlight'>PF12796 (Ankyrin repeats (3 copies))</span> in <span class='highlight'>26S proteasome non-ATPase regulatory subunit 10</span>. Showing 4 copies in chain <span class='highlight'>A [auth G]</span>.")
![The deposited structure of PDB entry 5vhr contains 2 copies of Pfam domain PF01851 (Proteasome/cyclosome repeat) in 26S proteasome non-ATPase regulatory subunit 2. Showing 2 copies in chain H [auth f].](https://www.ebi.ac.uk/pdbe/static/entry/5vhr_8_f_Pfam_PF01851_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5vhr</span> contains 2 copies of Pfam domain <span class='highlight'>PF01851 (Proteasome/cyclosome repeat)</span> in <span class='highlight'>26S proteasome non-ATPase regulatory subunit 2</span>. Showing 2 copies in chain <span class='highlight'>H [auth f]</span>.")
![The deposited structure of PDB entry 5vhr contains 1 copy of Pfam domain PF17781 (RPN1 N-terminal domain) in 26S proteasome non-ATPase regulatory subunit 2. Showing 1 copy in chain H [auth f].](https://www.ebi.ac.uk/pdbe/static/entry/5vhr_8_f_Pfam_PF17781_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5vhr</span> contains 1 copy of Pfam domain <span class='highlight'>PF17781 (RPN1 N-terminal domain)</span> in <span class='highlight'>26S proteasome non-ATPase regulatory subunit 2</span>. Showing 1 copy in chain <span class='highlight'>H [auth f]</span>.")
InterPro annotations