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Yeast V-ATPase in complex with Legionella pneumophila effector SidK (rotational state 3)

Source organisms:
Biochemical function: proton-transporting ATPase activity, rotational mechanism
Biological process: proton transmembrane transport
Cellular component: vacuolar proton-transporting V-type ATPase complex

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EC 7.1.2.2: H(+)-transporting two-sector ATPase

Reaction catalysed:
ATP + H(2)O + 4 H(+)(Side 1) = ADP + phosphate + 4 H(+)(Side 2)
Systematic name:
ATP phosphohydrolase (two-sector, H(+)-transporting)
Alternative Name(s):
  • ATP synthase
  • Bacterial Ca(2+)/Mg(2+) ATPase
  • Chloroplast ATPase
  • Coupling factors (F(o), F(1) and CF(1))
  • F(0)F(1)-ATPase
  • F(1)-ATPase
  • F(o)F(1)-ATPase
  • H(+)-transporting ATP synthase
  • H(+)-transporting ATPase
  • Mitochondrial ATPase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00137
Domain description: ATP synthase subunit C
Occurring in:
  1. V-type proton ATPase subunit c''
  2. V-type proton ATPase subunit c'
  3. V-type proton ATPase subunit c

PF00006
Domain description: ATP synthase alpha/beta family, nucleotide-binding domain
Occurring in:
  1. Endonuclease PI-SceI
  2. V-type proton ATPase subunit B

PF22919
Domain description: C-terminal domain of V and A type ATP synthase
Occurring in:
  1. Endonuclease PI-SceI
  2. V-type proton ATPase subunit B

PF02874
Domain description: ATP synthase alpha/beta family, beta-barrel domain
Occurring in:
  1. Endonuclease PI-SceI
  2. V-type proton ATPase subunit B

PF03179
Domain description: Vacuolar (H+)-ATPase G subunit
Occurring in:
  1. V-type proton ATPase subunit G

PF01991
Domain description: ATP synthase (E/31 kDa) subunit
Occurring in:
  1. V-type proton ATPase subunit E

PF16886
Domain description: ATPsynthase alpha/beta subunit N-term extension
Occurring in:
  1. Endonuclease PI-SceI

PF05493
Domain description: ATP synthase subunit H
Occurring in:
  1. V-type proton ATPase subunit e

PF01496
Domain description: V-type ATPase 116kDa subunit family
Occurring in:
  1. V-type proton ATPase subunit a, vacuolar isoform

PF01992
Domain description: ATP synthase (C/AC39) subunit
Occurring in:
  1. V-type proton ATPase subunit d

PF11698
Domain description: V-ATPase subunit H
Occurring in:
  1. V-type proton ATPase subunit H

PF03224
Domain description: V-ATPase subunit H
Occurring in:
  1. V-type proton ATPase subunit H

PF03223
Domain description: V-ATPase subunit C
Occurring in:
  1. V-type proton ATPase subunit C

PF01990
Domain description: ATP synthase (F/14-kDa) subunit
Occurring in:
  1. V-type proton ATPase subunit F

PF01813
Domain description: ATP synthase subunit D
Occurring in:
  1. V-type proton ATPase subunit D

InterPro InterPro annotations
IPR000245
Domain description: V-ATPase proteolipid subunit
Occurring in:
  1. V-type proton ATPase subunit c''
  2. V-type proton ATPase subunit c'
  3. V-type proton ATPase subunit c
IPR035921
Domain description: F/V-ATP synthase subunit C superfamily
Occurring in:
  1. V-type proton ATPase subunit c''
  2. V-type proton ATPase subunit c'
  3. V-type proton ATPase subunit c
IPR002379
Domain description: V-ATPase proteolipid subunit C-like domain
Occurring in:
  1. V-type proton ATPase subunit c''
  2. V-type proton ATPase subunit c'
  3. V-type proton ATPase subunit c
IPR011555
Domain description: V-ATPase proteolipid subunit C, eukaryotic
Occurring in:
  1. V-type proton ATPase subunit c'
  2. V-type proton ATPase subunit c
IPR005124
Domain description: Vacuolar (H+)-ATPase G subunit
Occurring in:
  1. V-type proton ATPase subunit G
IPR002842
Domain description: V-type ATPase subunit E
Occurring in:
  1. V-type proton ATPase subunit E
IPR022879
Domain description: V-type ATP synthase regulatory subunit B/beta
Occurring in:
  1. V-type proton ATPase subunit B
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Endonuclease PI-SceI
  2. V-type proton ATPase subunit B
IPR020003
Domain description: ATPase, alpha/beta subunit, nucleotide-binding domain, active site
Occurring in:
  1. Endonuclease PI-SceI
  2. V-type proton ATPase subunit B
IPR000194
Domain description: ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
Occurring in:
  1. Endonuclease PI-SceI
  2. V-type proton ATPase subunit B
IPR004100
Domain description: ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain
Occurring in:
  1. Endonuclease PI-SceI
  2. V-type proton ATPase subunit B
IPR022878
Domain description: V-type ATP synthase catalytic alpha chain
Occurring in:
  1. Endonuclease PI-SceI
IPR004908
Domain description: ATPase, V1 complex, subunit H
Occurring in:
  1. V-type proton ATPase subunit H
IPR004907
Domain description: ATPase, V1 complex, subunit C
Occurring in:
  1. V-type proton ATPase subunit C
IPR002699
Domain description: ATPase, V1 complex, subunit D
Occurring in:
  1. V-type proton ATPase subunit D
IPR038495
Domain description: V-type ATPase subunit E, C-terminal domain superfamily
Occurring in:
  1. V-type proton ATPase subunit E
IPR005723
Domain description: ATPase, V1 complex, subunit B
Occurring in:
  1. V-type proton ATPase subunit B
IPR024034
Domain description: ATPase, F1/V1 complex, beta/alpha subunit, C-terminal
Occurring in:
  1. Endonuclease PI-SceI
IPR031686
Domain description: ATPsynthase alpha/beta subunit, N-terminal extension
Occurring in:
  1. Endonuclease PI-SceI
IPR005725
Domain description: ATPase, V1 complex, subunit A
Occurring in:
  1. Endonuclease PI-SceI
IPR036121
Domain description: ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily
Occurring in:
  1. Endonuclease PI-SceI
IPR023366
Domain description: ATP synthase subunit alpha, N-terminal domain-like superfamily
Occurring in:
  1. Endonuclease PI-SceI
IPR008389
Domain description: ATPase, V0 complex, subunit e1/e2
Occurring in:
  1. V-type proton ATPase subunit e
IPR002490
Domain description: V-type ATPase, V0 complex, 116kDa subunit family
Occurring in:
  1. V-type proton ATPase subunit a, vacuolar isoform
IPR035067
Domain description: V-type ATPase subunit C/d
Occurring in:
  1. V-type proton ATPase subunit d
IPR016727
Domain description: ATPase, V0 complex, subunit d
Occurring in:
  1. V-type proton ATPase subunit d
IPR036906
Domain description: ATPase, V1 complex, subunit F superfamily
Occurring in:
  1. V-type proton ATPase subunit F
IPR026028
Domain description: ATPase, V0 complex, subunit 116kDa, eukaryotic
Occurring in:
  1. V-type proton ATPase subunit a, vacuolar isoform
IPR044911
Domain description: V-type ATP synthase c/d subunit, domain 3 superfamily
Occurring in:
  1. V-type proton ATPase subunit d
IPR002843
Domain description: ATPase, V0 complex, c/d subunit
Occurring in:
  1. V-type proton ATPase subunit d
IPR036079
Domain description: V-type ATP synthase subunit c/d subunit superfamily
Occurring in:
  1. V-type proton ATPase subunit d
IPR038497
Domain description: ATPase, V1 complex, subunit H, C-terminal domain superfamily
Occurring in:
  1. V-type proton ATPase subunit H
IPR011987
Domain description: ATPase, V1 complex, subunit H, C-terminal
Occurring in:
  1. V-type proton ATPase subunit H
IPR016024
Domain description: Armadillo-type fold
Occurring in:
  1. V-type proton ATPase subunit H
IPR011989
Domain description: Armadillo-like helical
Occurring in:
  1. V-type proton ATPase subunit H
IPR036132
Domain description: Vacuolar ATP synthase subunit C superfamily
Occurring in:
  1. V-type proton ATPase subunit C
IPR008218
Domain description: ATPase, V1 complex, subunit F
Occurring in:
  1. V-type proton ATPase subunit F
IPR005772
Domain description: ATPase, V1 complex, subunit F, eukaryotic
Occurring in:
  1. V-type proton ATPase subunit F

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