› 5vr2

X-ray diffraction
1.92Å resolution

mouse myocilin leucine zipper C-terminal 7 heptad repeat

Released:
DOI: 10.2210/pdb5vr2/pdb
PDB entry 5vr2 coloured by chain, front view.
PDB entry 5vr2 coloured by chain, side view.
PDB entry 5vr2 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure and Misfolding of the Flexible Tripartite Coiled-Coil Domain of Glaucoma-Associated Myocilin.
Hill SE, Nguyen E, Donegan RK, Patterson-Orazem AC, Hazel A, Gumbart JC, Lieberman RL
Structure 25 1697-1707.e5 (2017)
PMID: 29056483

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130715 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myocilin, N-terminal fragment Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 50 amino acids
Theoretical weight: 5.96 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: O70624 (Residues: 122-171; Coverage: 11%)
Gene names: Myoc, Tigr

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 85.129Å b: 48.746Å c: 55.798Å
α: 90° β: 105.97° γ: 90°
R-values:
R R work R free
0.192 0.187 0.24
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Physiological function of myocilin and its role in the pathogenesis of glaucoma in the trabecular meshwork (Review).
Wang et al. (2019)
5 more

5 mentions without citation

Structure and Misfolding of the Flexible Tripartite Coiled-Coil Domain of Glaucoma-Associated Myocilin.
Hill et al. (2017)
4 more