› 5w07

X-ray diffraction
2.65Å resolution

CRYSTAL STRUCTURE OF THE INHA FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH AN12855, EBSI 4333.

Released:
DOI: 10.2210/pdb5w07/pdb
Model geometry
Fit model/data
PDB entry 5w07 coloured by chain, front view.
PDB entry 5w07 coloured by chain, side view.
PDB entry 5w07 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis CDC1551
Entry authors: Abendroth J, Edwards TE, Lorimer D

Function and Biology Details

Reaction catalysed: 
An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-161510 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Enoyl-[acyl-carrier-protein] reductase [NADH] Chain: A
Molecule details ›
Chain: A
Length: 272 amino acids
Theoretical weight: 28.84 KDa
Source organism: Mycobacterium tuberculosis CDC1551
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WGR1 (Residues: 1-269; Coverage: 100%)
Gene names: MTCY277.05, Rv1484, inhA
Sequence domains: Enoyl-(Acyl carrier protein) reductase
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

1 bound ligand:
Ligand 9JA 1 x 9JA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: I4122
Unit cell:
a: 94.08Å b: 94.08Å c: 184.43Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.172 0.198
Expression system: Escherichia coli BL21(DE3)

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