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Tryptophan indole-lyase

Source organism: Proteus vulgaris
Biochemical function: carbon-carbon lyase activity
Biological process: aromatic amino acid metabolic process
Cellular component: not assigned

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EC 4.1.99.1: Tryptophanase

Reaction catalysed:
(1a) L-tryptophan = indole + 2-aminoprop-2-enoate
Systematic name:
L-tryptophan indole-lyase (deaminating; pyruvate-forming)
Alternative Name(s):
  • L-tryptophan indole-lyase
  • L-tryptophan indole-lyase (deaminating)
  • L-tryptophanase
  • TNase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01212
Domain description: Beta-eliminating lyase
Occurring in:
  1. Tryptophanase
The deposited structure of PDB entry 5w1b contains 4 copies of Pfam domain PF01212 (Beta-eliminating lyase) in Tryptophanase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR018176
Domain description: Tryptophanase, conserved site
Occurring in:
  1. Tryptophanase
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. Tryptophanase
IPR001597
Domain description: Aromatic amino acid beta-eliminating lyase/threonine aldolase
Occurring in:
  1. Tryptophanase
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. Tryptophanase
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. Tryptophanase
IPR013440
Domain description: Tryptophanase
Occurring in:
  1. Tryptophanase
IPR011166
Domain description: Beta-eliminating lyase family
Occurring in:
  1. Tryptophanase

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