› 5w7v

Electron Microscopy
3.8Å resolution

CryoEM structure of the segment, DLIIKGISVHI, assembled into a triple-helical fibril

Released:
DOI: 10.2210/pdb5w7v/pdb
PDB entry 5w7v coloured by chain, front view.
PDB entry 5w7v coloured by chain, side view.
PDB entry 5w7v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2.
Guenther EL, Ge P, Trinh H, Sawaya MR, Cascio D, Boyer DR, Gonen T, Zhou ZH, Eisenberg DS
Nat Struct Mol Biol 25 311-319 (2018)
PMID: 29531287
Related structures: EMD-8781

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo 270-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171565 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TAR DNA-binding protein 43 Chains: 0, 1, 2, 3, 4, 5, 6, 7, 8
Molecule details ›
Chains: 0, 1, 2, 3, 4, 5, 6, 7, 8
Length: 11 amino acids
Theoretical weight: 1.21 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q13148 (Residues: 247-257; Coverage: 3%)
Gene names: TARDBP, TDP43

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-8781
Expression system: Not provided

Quick links

Citations

11 review citations

Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis.
Prasad et al. (2019)
10 more

2 mentions without citation

Structural Insights Into TDP-43 and Effects of Post-translational Modifications.
François-Moutal et al. (2019)
1 more