› 5w96

Solution NMR

Solution structure of phage derived peptide inhibitor of frizzled 7 receptor

Released:
DOI: 10.2210/pdb5w96/pdb
PDB entry 5w96 coloured by chain, ensemble of 20 models, front view.
PDB entry 5w96 coloured by chain, ensemble of 20 models, side view.
PDB entry 5w96 coloured by chain, ensemble of 20 models, top view.
Source organism: unidentified
Primary publication:
A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.
Nile AH, de Sousa E Melo F, Mukund S, Piskol R, Hansen S, Zhou L, Zhang Y, Fu Y, Gogol EB, Kömüves LG, Modrusan Z, Angers S, Franke Y, Koth C, Fairbrother WJ, Wang W, de Sauvage FJ, Hannoush RN
Nat Chem Biol 14 582-590 (2018)
PMID: 29632413

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166258 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fz7 binding peptide Chains: A, B
Molecule details ›
Chains: A, B
Length: 14 amino acids
Theoretical weight: 1.76 KDa
Source organism: unidentified
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 46%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

19 review citations

Targeting the Wnt/β-catenin signaling pathway in cancer.
Zhang et al. (2020)
18 more