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Structure of human Ketohexokinase complexed with hits from fragment screening

Source organism: Homo sapiens
Biochemical function: fructose binding
Biological process: regulation of glycogen metabolic process
Cellular component: extracellular exosome

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EC 2.7.1.3: Ketohexokinase

Reaction catalysed:
ATP + D-fructose = ADP + D-fructose 1-phosphate
Systematic name:
ATP:D-fructose 1-phosphotransferase
Alternative Name(s):
  • Hepatic fructokinase
  • Ketohexokinase (phosphorylating)

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00294
Domain description: pfkB family carbohydrate kinase
Occurring in:
  1. Ketohexokinase
The deposited structure of PDB entry 5wbr contains 2 copies of Pfam domain PF00294 (pfkB family carbohydrate kinase) in Ketohexokinase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR029056
Domain description: Ribokinase-like
Occurring in:
  1. Ketohexokinase
IPR034093
Domain description: Ketohexokinase
Occurring in:
  1. Ketohexokinase
IPR011611
Domain description: Carbohydrate kinase PfkB
Occurring in:
  1. Ketohexokinase
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Ketohexokinase

Structure domain

CATH CATH domain
3.40.1190.20
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase
Homology: UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase
Occurring in:
  1. Ketohexokinase
The deposited structure of PDB entry 5wbr contains 2 copies of CATH domain 3.40.1190.20 (UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase) in Ketohexokinase. Showing 1 copy in chain B.

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