Function and Biology Details
Reaction catalysed:
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine(27) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(27)
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-514866 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Polycomb protein EED
Molecule details ›
Chain: A
Length: 605 amino acids
Theoretical weight: 66.02 KDa
Source organism: Thermochaetoides thermophila DSM 1495
Expression system: Saccharomyces cerevisiae
UniProt:
Sequence domains:
Length: 605 amino acids
Theoretical weight: 66.02 KDa
Source organism: Thermochaetoides thermophila DSM 1495
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical:
G0S8H7 (Residues: 1-565; Coverage: 100%)
Sequence domains:
Histone-lysine N-methyltransferase EZH2; Polycomb protein SUZ12
Molecule details ›
Chain: B
Length: 936 amino acids
Theoretical weight: 106.8 KDa
Source organism: Thermochaetoides thermophila DSM 1495
Expression system: Saccharomyces cerevisiae
UniProt:
Sequence domains:
Length: 936 amino acids
Theoretical weight: 106.8 KDa
Source organism: Thermochaetoides thermophila DSM 1495
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical: G0SDW4 (Residues: 191-950; Coverage: 50%)
- Canonical: G0RYC6 (Residues: 530-691; Coverage: 22%)
Sequence domains:
