EC 2.7.11.15: [Beta-adrenergic-receptor] kinase
Reaction catalysed:
ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate
Systematic name:
ATP:[beta-adrenergic-receptor] phosphotransferase
Alternative Name(s):
- ADRBK1
- ATP:beta-adrenergic-receptor phosphotransferase
- Adrenergic receptor kinase
- BARK1
- Beta(2)ARK
- Beta-AR kinase
- Beta-ARK
- Beta-ARK 1
- Beta-ARK 2
- Beta-ARK1
- Beta-adrenergic receptor-specific kinase
- Beta-adrenergic-receptor kinase
- Beta-adrenergic-receptor kinase (phosphorylating)
- Beta-adrenoceptor kinase
- Beta-adrenoceptor kinase 1
- Beta-adrenoceptor kinase 2
- Beta-receptor kinase
- GRK2
- GRK3
- STK15
- [Beta-adrenergic-receptor] kinase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
Structure domains
CATH domains
1.10.287.1270
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Helix Hairpins
Homology:
Helix Hairpins
Occurring in:

3.30.200.20
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Phosphorylase Kinase; domain 1
Homology:
Phosphorylase Kinase; domain 1
Occurring in:

4.10.260.10
Class:
Few Secondary Structures
Architecture:
Irregular
Topology:
G Protein Gi Gamma 2
Homology:
Transducin (heterotrimeric G protein), gamma chain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>5wg3</span> contains 1 copy of CATH domain <span class='highlight'>4.10.260.10 (G Protein Gi Gamma 2)</span> in <span class='highlight'>Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2</span>. Showing 1 copy in chain <span class='highlight'>C [auth G]</span>. The deposited structure of PDB entry 5wg3 contains 1 copy of CATH domain 4.10.260.10 (G Protein Gi Gamma 2) in Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2. Showing 1 copy in chain C [auth G].](https://www.ebi.ac.uk/pdbe/static/entry/5wg3_3_G_CATH_4.10.260.10_image-200x200.png)
2.130.10.10
Class:
Mainly Beta
Architecture:
7 Propeller
Topology:
Methylamine Dehydrogenase; Chain H
Homology:
YVTN repeat-like/Quinoprotein amine dehydrogenase
Occurring in:

2.30.29.30
Class:
Mainly Beta
Architecture:
Roll
Topology:
PH-domain like
Homology:
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Occurring in:

1.10.510.10
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Transferase(Phosphotransferase); domain 1
Homology:
Transferase(Phosphotransferase) domain 1
Occurring in:
