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Crystal structure of the influenza virus PA endonuclease (E119D mutant) in complex with inhibitor 9b (SRI-30101)

Source organism: Influenza A virus (A/California/04/2009(H1N1))
Biochemical function: RNA binding
Biological process: viral RNA genome replication
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

InterPro InterPro annotations
IPR001009
Domain description: Influenza RNA-dependent RNA polymerase subunit PA
Occurring in:
  1. Polymerase acidic protein
IPR038372
Domain description: Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain
Occurring in:
  1. Polymerase acidic protein

Structure domain

CATH CATH domain
3.40.91.90
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Restriction Endonuclease
Homology: Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain
Occurring in:
  1. Polymerase acidic protein
The deposited structure of PDB entry 5wg9 contains 1 copy of CATH domain 3.40.91.90 (Restriction Endonuclease) in Polymerase acidic protein. Showing 1 copy in chain A.

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