› 5wia

X-ray diffraction
1Å resolution

Crystal structure of the segment, GNNSYS, from the low complexity domain of TDP-43, residues 370-375

Released:
DOI: 10.2210/pdb5wia/pdb
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PDB entry 5wia coloured by chain, front view.
PDB entry 5wia coloured by chain, side view.
PDB entry 5wia coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS
OpenAccess logo Nat Struct Mol Biol 25 463-471 (2018)
PMID: 29786080

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171560 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TAR DNA-binding protein 43 Chain: A
Molecule details ›
Chain: A
Length: 6 amino acids
Theoretical weight: 641 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q13148 (Residues: 370-375; Coverage: 1%)
Gene names: TARDBP, TDP43

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 4.786Å b: 15.617Å c: 40.679Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.157 0.155 0.181
Expression system: Not provided

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Citations

31 review citations

The molecular language of membraneless organelles.
Gomes et al. (2019)
30 more

3 mentions without citation

Structural Insights Into TDP-43 and Effects of Post-translational Modifications.
François-Moutal et al. (2019)
2 more

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