› 5wj9

Electron Microscopy
3.49Å resolution

Human TRPML1 channel structure in agonist-bound open conformation

Released:
DOI: 10.2210/pdb5wj9/pdb
PDB entry 5wj9 coloured by chain, front view.
PDB entry 5wj9 coloured by chain, side view.
PDB entry 5wj9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human TRPML1 channel structures in open and closed conformations.
Schmiege P, Fine M, Blobel G, Li X
Nature 550 366-370 (2017)
PMID: 29019983
Related structures: EMD-8841

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190453 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mucolipin-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 580 amino acids
Theoretical weight: 65.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9GZU1 (Residues: 1-580; Coverage: 100%)
Gene names: MCOLN1, ML4, MSTP080, TRPML1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand AQV 4 x AQV
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.49Å
Relevant EMDB volumes: EMD-8841
Expression system: Homo sapiens

Quick links

Citations

31 review citations

Cryo-EM in drug discovery: achievements, limitations and prospects.
Renaud et al. (2018)
30 more

14 mentions without citation

Transient Receptor Potential Channels and Calcium Signaling.
Vangeel et al. (2019)
13 more