› 5wjm

X-ray diffraction
2.9Å resolution

Crystal Structure of Mouse Cadherin-23 EC17-18

Released:
DOI: 10.2210/pdb5wjm/pdb
PDB entry 5wjm coloured by chain, front view.
PDB entry 5wjm coloured by chain, side view.
PDB entry 5wjm coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
Jaiganesh A, De-la-Torre P, Patel AA, Termine DJ, Velez-Cortes F, Chen C, Sotomayor M
Structure 26 1210-1225.e4 (2018)
PMID: 30033219

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-573171 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-23 Chain: A
Molecule details ›
Chain: A
Length: 225 amino acids
Theoretical weight: 25.09 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q99PF4 (Residues: 1739-1954; Coverage: 7%)
Gene name: Cdh23
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

3 bound ligands:
Ligand CA 6 x CA
Ligand K 1 x K
Ligand MPD 2 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P43212
Unit cell:
a: 122.476Å b: 122.476Å c: 43.603Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.2 0.266
Expression system: Escherichia coli BL21

Quick links

Citations

2 review citations

Tonotopy in calcium homeostasis and vulnerability of cochlear hair cells.
Fettiplace et al. (2019)
1 more

3 mentions without citation

Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
Jaiganesh et al. (2018)
2 more