Function and Biology

Bromide sites in the structure of an acid sensing ion channel in a resting state

Source organism: Gallus gallus
Biochemical function: ligand-gated sodium channel activity
Biological process: sodium ion transport
Cellular component: membrane

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00858
Domain description: Amiloride-sensitive sodium channel
Occurring in:
  1. Acid-sensing ion channel 1
The deposited structure of PDB entry 5wky contains 3 copies of Pfam domain PF00858 (Amiloride-sensitive sodium channel) in Acid-sensing ion channel 1. Showing 1 copy in chain C [auth B].

InterPro InterPro annotations
IPR001873
Domain description: Epithelial sodium channel
Occurring in:
  1. Acid-sensing ion channel 1
IPR020903
Domain description: Epithelial sodium channel, conserved site
Occurring in:
  1. Acid-sensing ion channel 1
IPR004724
Domain description: Epithelial sodium channel, chordates
Occurring in:
  1. Acid-sensing ion channel 1

Structure domains

CATH CATH domains
2.60.470.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Acid-sensing ion channels like fold
Homology: Acid-sensing ion channels like domains
Occurring in:
  1. Acid-sensing ion channel 1
The deposited structure of PDB entry 5wky contains 3 copies of CATH domain 2.60.470.10 (Acid-sensing ion channels like fold) in Acid-sensing ion channel 1. Showing 1 copy in chain C [auth B].
1.10.3590.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: acid-sensing ion channel 1 fold
Homology: acid-sensing ion channel 1 domain
Occurring in:
  1. Acid-sensing ion channel 1
The deposited structure of PDB entry 5wky contains 3 copies of CATH domain 1.10.3590.10 (acid-sensing ion channel 1 fold) in Acid-sensing ion channel 1. Showing 1 copy in chain C [auth B].
1.10.287.770
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helix Hairpins
Homology: YojJ-like
Occurring in:
  1. Acid-sensing ion channel 1
The deposited structure of PDB entry 5wky contains 3 copies of CATH domain 1.10.287.770 (Helix Hairpins) in Acid-sensing ion channel 1. Showing 1 copy in chain C [auth B].
1.10.287.820
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helix Hairpins
Homology: Acid-sensing ion channel domain
Occurring in:
  1. Acid-sensing ion channel 1
The deposited structure of PDB entry 5wky contains 3 copies of CATH domain 1.10.287.820 (Helix Hairpins) in Acid-sensing ion channel 1. Showing 1 copy in chain C [auth B].