› 5wn9

X-ray diffraction
1.55Å resolution

Structure of antibody 2D10 bound to the central conserved region of RSV G

Released:
DOI: 10.2210/pdb5wn9/pdb
PDB entry 5wn9 coloured by chain, front view.
PDB entry 5wn9 coloured by chain, side view.
PDB entry 5wn9 coloured by chain, top view.
Source organisms:
Primary publication:
Structures of respiratory syncytial virus G antigen bound to broadly neutralizing antibodies.
Fedechkin SO, George NL, Wolff JT, Kauvar LM, DuBois RM
Sci Immunol 3 (2018)
PMID: 29523582

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-230773 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
scFv 2D10 Chain: H
Molecule details ›
Chain: H
Length: 260 amino acids
Theoretical weight: 27.22 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
Mature secreted glycoprotein G Chain: A
Molecule details ›
Chain: A
Length: 29 amino acids
Theoretical weight: 3.27 KDa
Source organism: Human respiratory syncytial virus A2
Expression system: Not provided
UniProt:
  • Canonical: P03423 (Residues: 168-196; Coverage: 10%)
Gene name: G

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 44.843Å b: 56.387Å c: 126.148Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.169 0.185
Expression systems:
  • Drosophila melanogaster
  • Not provided

Quick links

Citations

13 review citations

Fc-Mediated Antibody Effector Functions During Respiratory Syncytial Virus Infection and Disease.
van Erp et al. (2019)
12 more

4 mentions without citation

Structures of respiratory syncytial virus G antigen bound to broadly neutralizing antibodies.
Fedechkin et al. (2018)
3 more