› 5wna

X-ray diffraction
2.4Å resolution

Structure of antibody 3D3 bound to the central conserved region of RSV G

Released:
DOI: 10.2210/pdb5wna/pdb
PDB entry 5wna coloured by chain, front view.
PDB entry 5wna coloured by chain, side view.
PDB entry 5wna coloured by chain, top view.
Source organisms:
Primary publication:
Structures of respiratory syncytial virus G antigen bound to broadly neutralizing antibodies.
Fedechkin SO, George NL, Wolff JT, Kauvar LM, DuBois RM
Sci Immunol 3 (2018)
PMID: 29523582

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-230774 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
mAb 3D3 Fab heavy chain Chains: C, H
Molecule details ›
Chains: C, H
Length: 231 amino acids
Theoretical weight: 24.78 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
mAb 3D3 Fab light chain Chains: D, L
Molecule details ›
Chains: D, L
Length: 213 amino acids
Theoretical weight: 23.49 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
Mature secreted glycoprotein G Chains: A, B
Molecule details ›
Chains: A, B
Length: 45 amino acids
Theoretical weight: 5.31 KDa
Source organism: Human respiratory syncytial virus A2
Expression system: Escherichia coli
UniProt:
  • Canonical: P03423 (Residues: 161-197; Coverage: 12%)
Gene name: G

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P21
Unit cell:
a: 64.62Å b: 135.01Å c: 73.78Å
α: 90° β: 107.45° γ: 90°
R-values:
R R work R free
0.194 0.192 0.246
Expression systems:
  • Cricetulus griseus
  • Escherichia coli

Quick links

Citations

13 review citations

Fc-Mediated Antibody Effector Functions During Respiratory Syncytial Virus Infection and Disease.
van Erp et al. (2019)
12 more

4 mentions without citation

Structures of respiratory syncytial virus G antigen bound to broadly neutralizing antibodies.
Fedechkin et al. (2018)
3 more