› 5wov

Solution NMR

Solution NMR structure of cyclotide MCoTI-I

Released:
DOI: 10.2210/pdb5wov/pdb
PDB entry 5wov coloured by chain, ensemble of 20 models, front view.
PDB entry 5wov coloured by chain, ensemble of 20 models, side view.
PDB entry 5wov coloured by chain, ensemble of 20 models, top view.
Source organism: Momordica cochinchinensis
Primary publication:
Targeted Delivery of Cyclotides via Conjugation to a Nanobody.
Kwon S, Duarte JN, Li Z, Ling JJ, Cheneval O, Durek T, Schroeder CI, Craik DJ, Ploegh HL
ACS Chem Biol 13 2973-2980 (2018)
PMID: 30248263

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166288 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Two inhibitor peptide topologies 2 Chain: A
Molecule details ›
Chain: A
Length: 34 amino acids
Theoretical weight: 3.51 KDa
Source organism: Momordica cochinchinensis
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 80%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

5 review citations

Nanobodies: Next Generation of Cancer Diagnostics and Therapeutics.
Yang et al. (2020)
4 more