Function and Biology Details
Reactions catalysed:
Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Serine protease NS3 (preferred)
PDBe Complex ID:
PDB-CPX-178354 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SSRF BEAMLINE BL17U1
Spacegroup:
P42212
Expression system: Escherichia coli BL21(DE3)