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Complex structure of ipilimumab-scFv and CTLA-4

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: regulation of T cell proliferation
Cellular component: membrane

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GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF07686
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Cytotoxic T-lymphocyte protein 4
The deposited structure of PDB entry 5xj3 contains 4 copies of Pfam domain PF07686 (Immunoglobulin V-set domain) in Cytotoxic T-lymphocyte protein 4. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. ipilimumab-VH
  2. ipilimumab-VL
  3. Cytotoxic T-lymphocyte protein 4
IPR008096
Domain description: Cytotoxic T-lymphocyte antigen 4
Occurring in:
  1. Cytotoxic T-lymphocyte protein 4
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. ipilimumab-VH
  2. ipilimumab-VL
  3. Cytotoxic T-lymphocyte protein 4
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. ipilimumab-VH
  2. ipilimumab-VL
  3. Cytotoxic T-lymphocyte protein 4
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. ipilimumab-VH
  2. ipilimumab-VL
  3. Cytotoxic T-lymphocyte protein 4
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. ipilimumab-VH
  2. ipilimumab-VL
IPR040216
Domain description: Cytotoxic T-lymphocyte protein 4/CD28
Occurring in:
  1. Cytotoxic T-lymphocyte protein 4

Structure domain

CATH CATH domain
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. ipilimumab-VL
  2. Cytotoxic T-lymphocyte protein 4
The deposited structure of PDB entry 5xj3 contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in ipilimumab-VL. Showing 1 copy in chain B.
The deposited structure of PDB entry 5xj3 contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Cytotoxic T-lymphocyte protein 4. Showing 1 copy in chain C.

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