› 5xjp

X-ray diffraction
1.6Å resolution

Crystal structure of response regulator AdeR receiver domain with Mg

Released:
DOI: 10.2210/pdb5xjp/pdb
PDB entry 5xjp coloured by chain, front view.
PDB entry 5xjp coloured by chain, side view.
PDB entry 5xjp coloured by chain, top view.
Source organism: Acinetobacter baumannii
Primary publication:
Mechanistic insight into how multidrug resistant Acinetobacter baumannii response regulator AdeR recognizes an intercistronic region.
Wen Y, Ouyang Z, Yu Y, Zhou X, Pei Y, Devreese B, Higgins PG, Zheng F
OpenAccess logo Nucleic Acids Res 45 9773-9787 (2017)
PMID: 28934482

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180356 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
AdeR Chain: A
Molecule details ›
Chain: A
Length: 145 amino acids
Theoretical weight: 16.6 KDa
Source organism: Acinetobacter baumannii
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6TA00 (Residues: 2-138; Coverage: 56%)
Gene names: GSE42_10430, adeR
Sequence domains: Response regulator receiver domain
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P3221
Unit cell:
a: 64.753Å b: 64.753Å c: 49.962Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.179 0.176 0.207
Expression system: Escherichia coli

Quick links

Citations

11 citation in other articles

Diversity of mutations in regulatory genes of resistance-nodulation-cell division efflux pumps in association with tigecycline resistance in Acinetobacter baumannii.
Gerson et al. (2018)
10 more

1 mention without citation

Mechanistic insight into how multidrug resistant Acinetobacter baumannii response regulator AdeR recognizes an intercistronic region.
Wen et al. (2017)