› 5xl9

X-ray diffraction
2.39Å resolution

The structure of hemagglutinin G228S mutant from an avian-origin H4N6 influenza virus in complex with avian receptor analog LSTa

Released:
DOI: 10.2210/pdb5xl9/pdb
PDB entry 5xl9 coloured by chain, front view.
PDB entry 5xl9 coloured by chain, side view.
PDB entry 5xl9 coloured by chain, top view.
Source organism: Influenza A virus (A/duck/Czechoslovakia/1956(H4N6))
Primary publication:
Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4.
Song H, Qi J, Xiao H, Bi Y, Zhang W, Xu Y, Wang F, Shi Y, Gao GF
Cell Rep 20 1201-1214 (2017)
PMID: 28768203

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148691 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hemagglutinin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 503 amino acids
Theoretical weight: 56.32 KDa
Source organism: Influenza A virus (A/duck/Czechoslovakia/1956(H4N6))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P19696 (Residues: 17-519; Coverage: 92%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin (Ha1 Chain); Chain: A; domain 1

Ligands and Environments

2 bound ligands:
Ligand NAG 6 x NAG
Ligand SIA 1 x SIA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P21
Unit cell:
a: 65.118Å b: 115.161Å c: 132.032Å
α: 90° β: 102.23° γ: 90°
R-values:
R R work R free
0.186 0.183 0.229
Expression system: Trichoplusia ni

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Citations

8 review citations

Influenza Hemagglutinin and Neuraminidase: Yin⁻Yang Proteins Coevolving to Thwart Immunity.
Kosik et al. (2019)
7 more