› 5xm7

X-ray diffraction
1.96Å resolution

Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido)-N-hydroxy-4-methylpentanamide

Released:
DOI: 10.2210/pdb5xm7/pdb
PDB entry 5xm7 coloured by chain, front view.
PDB entry 5xm7 coloured by chain, side view.
PDB entry 5xm7 coloured by chain, top view.
Source organism: Plasmodium falciparum FcB1/Columbia
Primary publication:
Development of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual inhibitors: Biological evaluation and structural characterization by cocrystallization
Marapaka AK, Sankoju P, Zhang G, Ding Y, Ma C, Pillalamarri V, Sudhakar P, Reddi B, Sijwali PS, Zhang Y, Addlagatta A
Chin. Chem. Lett. 33 2550-2554 (2022)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132164 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:

Ligands and Environments

4 bound ligands:
Ligand ZN 1 x ZN
Ligand MG 3 x MG
Ligand GOL 11 x GOL
Ligand 89X 1 x 89X
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P212121
Unit cell:
a: 74.462Å b: 109.103Å c: 112.372Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.168 0.219
Expression system: Escherichia coli

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