› 5y49

X-ray diffraction
2.4Å resolution

A moderator XD22 binding to bile acid receptor

Released:
DOI: 10.2210/pdb5y49/pdb
Model geometry
Fit model/data
PDB entry 5y49 coloured by chain, front view.
PDB entry 5y49 coloured by chain, side view.
PDB entry 5y49 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Lu Y, Li Y

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172333 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bile acid receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 227 amino acids
Theoretical weight: 26.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96RI1 (Residues: 259-485; Coverage: 47%)
Gene names: BAR, FXR, HRR1, NR1H4, RIP14
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chains: D, E
Molecule details ›
Chains: D, E
Length: 11 amino acids
Theoretical weight: 1.39 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 741-751; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

1 bound ligand:
Ligand XD5 2 x XD5
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P2
Unit cell:
a: 73.805Å b: 34.853Å c: 117.305Å
α: 90° β: 98.21° γ: 90°
R-values:
R R work R free
0.214 0.212 0.253
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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