› 5y4f

X-ray diffraction
1.95Å resolution

Crystal Structure of AnkB Ankyrin Repeats R13-24 in complex with autoinhibition segment AI-c

Released:
DOI: 10.2210/pdb5y4f/pdb
PDB entry 5y4f coloured by chain, front view.
PDB entry 5y4f coloured by chain, side view.
PDB entry 5y4f coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Autoinhibition of ankyrin-B/G membrane target bindings by intrinsically disordered segments from the tail regions.
Chen K, Li J, Wang C, Wei Z, Zhang M
Elife 6 (2017)
PMID: 28841137

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169571 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ankyrin-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 444 amino acids
Theoretical weight: 47.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q01484 (Residues: 430-873; Coverage: 11%)
Gene names: ANK2, ANKB
Sequence domains: Ankyrin repeat
Structure domains: Ankyrin repeat-containing domain

Ligands and Environments

2 bound ligands:
Ligand CA 1 x CA
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P212121
Unit cell:
a: 29.304Å b: 127.803Å c: 257.55Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.22
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Ankyrins: Roles in synaptic biology and pathology.
Smith et al. (2018)
2 more

1 mention without citation

Autoinhibition of ankyrin-B/G membrane target bindings by intrinsically disordered segments from the tail regions.
Chen et al. (2017)