› 5yhu

X-ray diffraction
1.85Å resolution

Crystal structure of the DNA-binding domain of human myelin-gene regulatory factor

Released:
DOI: 10.2210/pdb5yhu/pdb
PDB entry 5yhu coloured by chain, front view.
PDB entry 5yhu coloured by chain, side view.
PDB entry 5yhu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the DNA-binding domain of human myelin-gene regulatory factor reveals its potential protein-DNA recognition mode.
Chen B, Zhu Y, Ye S, Zhang R
J Struct Biol 203 170-178 (2018)
PMID: 29729323

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195126 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myelin regulatory factor, N-terminal Chains: A, B
Molecule details ›
Chains: A, B
Length: 255 amino acids
Theoretical weight: 28.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y2G1 (Residues: 332-578; Coverage: 22%)
Gene names: C11orf9, KIAA0954, MRF, MYRF
Sequence domains: NDT80 / PhoG like DNA-binding family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: R32
Unit cell:
a: 105.122Å b: 105.122Å c: 297.413Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.205 0.204 0.228
Expression system: Escherichia coli

Quick links

Citations

1 review citation

A Glance at the Molecules That Regulate Oligodendrocyte Myelination.
Wang et al. (2022)
5 other articles

1 mention without citation

Nanophthalmos patient with a THR518MET mutation in MYRF, a case report.
Hagedorn et al. (2020)