› 5yrn

Electron Microscopy
4.1Å resolution

Structure of RIP2 CARD domain

Released:
DOI: 10.2210/pdb5yrn/pdb
PDB entry 5yrn coloured by chain, front view.
PDB entry 5yrn coloured by chain, side view.
PDB entry 5yrn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of RIP2 activation and signaling.
Gong Q, Long Z, Zhong FL, Teo DET, Jin Y, Yin Z, Boo ZZ, Zhang Y, Zhang J, Yang R, Bhushan S, Reversade B, Li Z, Wu B
OpenAccess logo Nat Commun 9 4993 (2018)
PMID: 30478312
Related structures: EMD-6842

Function and Biology Details

Reactions catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128908 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-interacting serine/threonine-protein kinase 2 Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 111 amino acids
Theoretical weight: 12.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43353 (Residues: 434-540; Coverage: 20%)
Gene names: CARDIAK, RICK, RIP2, RIPK2, UNQ277/PRO314/PRO34092
Sequence domains: Caspase recruitment domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.1Å
Relevant EMDB volumes: EMD-6842
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Structures, functions, and mechanisms of filament forming enzymes: a renaissance of enzyme filamentation.
Park et al. (2019)
12 more

1 mention without citation

Structural basis of RIP2 activation and signaling.
Gong et al. (2018)