› 5yxl

X-ray diffraction
2.24Å resolution

A ligand M binding to FXR

Released:
DOI: 10.2210/pdb5yxl/pdb
Model geometry
Fit model/data
PDB entry 5yxl coloured by chain, front view.
PDB entry 5yxl coloured by chain, side view.
PDB entry 5yxl coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Yi L, Yong L

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172333 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bile acid receptor Chains: A, C
Molecule details ›
Chains: A, C
Length: 229 amino acids
Theoretical weight: 26.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96RI1 (Residues: 258-486; Coverage: 47%)
Gene names: BAR, FXR, HRR1, NR1H4, RIP14
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chains: B, D
Molecule details ›
Chains: B, D
Length: 8 amino acids
Theoretical weight: 977 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 743-750; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

1 bound ligand:
Ligand NIW 2 x NIW
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P212121
Unit cell:
a: 35.509Å b: 117.341Å c: 151.137Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 0.223
Expression systems:
  • Escherichia coli
  • Not provided

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