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Crystal structure of Arabidopsis thaliana HPPD complexed with Benquitrione

Source organism: Arabidopsis thaliana
Biochemical function: dioxygenase activity
Biological process: aromatic amino acid metabolic process
Cellular component: cytoplasm

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EC 1.13.11.27: 4-hydroxyphenylpyruvate dioxygenase

Reaction catalysed:
4-hydroxyphenylpyruvate + O(2) = homogentisate + CO(2)
Systematic name:
4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)
Alternative Name(s):
  • 4-hydroxyphenylpyruvate hydroxylase
  • 4-hydroxyphenylpyruvic acid dioxygenase
  • p-hydroxyphenylpyruvate dioxygenase
  • p-hydroxyphenylpyruvate hydroxylase
  • p-hydroxyphenylpyruvate oxidase
  • p-hydroxyphenylpyruvic acid hydroxylase
  • p-hydroxyphenylpyruvic hydroxylase
  • p-hydroxyphenylpyruvic oxidase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00903
Domain description: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
Occurring in:
  1. 4-hydroxyphenylpyruvate dioxygenase
The deposited structure of PDB entry 5yy7 contains 2 copies of Pfam domain PF00903 (Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily) in 4-hydroxyphenylpyruvate dioxygenase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR005956
Domain description: 4-hydroxyphenylpyruvate dioxygenase
Occurring in:
  1. 4-hydroxyphenylpyruvate dioxygenase
IPR029068
Domain description: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
Occurring in:
  1. 4-hydroxyphenylpyruvate dioxygenase
IPR037523
Domain description: Vicinal oxygen chelate (VOC) domain
Occurring in:
  1. 4-hydroxyphenylpyruvate dioxygenase
IPR004360
Domain description: Glyoxalase/fosfomycin resistance/dioxygenase domain
Occurring in:
  1. 4-hydroxyphenylpyruvate dioxygenase
IPR041735
Domain description: 4-hydroxyphenylpyruvate dioxygenase, C-terminal
Occurring in:
  1. 4-hydroxyphenylpyruvate dioxygenase
IPR041736
Domain description: 4-hydroxyphenylpyruvate dioxygenase, N-terminal
Occurring in:
  1. 4-hydroxyphenylpyruvate dioxygenase

Structure domain

CATH CATH domain
3.10.180.10
Class: Alpha Beta
Architecture: Roll
Topology: 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1
Homology: 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1
Occurring in:
  1. 4-hydroxyphenylpyruvate dioxygenase
The deposited structure of PDB entry 5yy7 contains 4 copies of CATH domain 3.10.180.10 (2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1) in 4-hydroxyphenylpyruvate dioxygenase. Showing 2 copies in chain B.

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