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The crystal structure of kinetochore subunits Cenp-H/I/K triple complex

X-ray diffraction
2.199Å resolution
PDB entry 5z08 coloured by chain, front view.
PDB entry 5z08 coloured by chain, side view.
PDB entry 5z08 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Centromere protein H C-terminal domain-containing protein and Cenp-I
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Multimeric state: hetero tetramer
Accessible surface area: 28028.58 Å2
Buried surface area: 6763.12 Å2
Dissociation area: 1,877.82 Å2
Dissociation energy (ΔGdiss): -7.72 kcal/mol
Dissociation entropy (TΔSdiss): 25.08 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-124105

Macromolecules

Cenp-I
Chains: A, B
Length: 229 amino acids
Theoretical weight: 25.79 KDa
Source organism: Thermochaetoides thermophila DSM 1495
Expression system: Escherichia coli
UniProt:
  • Canonical: G0SFF7 (Residues: 1-229; Coverage: 34%)
Gene name: CTHT_0061880
Pfam: Mis6
InterPro: Centromere protein I
Cenp-I in PDB entry 5z08, assembly 1, front view.
Cenp-I in PDB entry 5z08, assembly 1, side view.
Cenp-I in PDB entry 5z08, assembly 1, top view.
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Centromere protein H C-terminal domain-containing protein
Chain: C
Length: 168 amino acids
Theoretical weight: 18.87 KDa
Source organism: Thermothielavioides terrestris NRRL 8126
Expression system: Escherichia coli
UniProt:
  • Canonical: G2R3T1 (Residues: 161-328; Coverage: 51%)
Gene name: THITE_2065850
Pfam: Centromere-associated protein K
InterPro: Centromere protein Cenp-K
Centromere protein H C-terminal domain-containing protein in PDB entry 5z08, assembly 1, front view.
Centromere protein H C-terminal domain-containing protein in PDB entry 5z08, assembly 1, side view.
Centromere protein H C-terminal domain-containing protein in PDB entry 5z08, assembly 1, top view.
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Centromere protein H C-terminal domain-containing protein
Chain: D
Length: 45 amino acids
Theoretical weight: 5.2 KDa
Source organism: Thermothielavioides terrestris NRRL 8126
Expression system: Escherichia coli
UniProt:
  • Canonical: G2R207 (Residues: 184-228; Coverage: 20%)
Gene name: THITE_2113209
InterPro: Centromere protein H, C-terminal
Centromere protein H C-terminal domain-containing protein in PDB entry 5z08, assembly 1, front view.
Centromere protein H C-terminal domain-containing protein in PDB entry 5z08, assembly 1, side view.
Centromere protein H C-terminal domain-containing protein in PDB entry 5z08, assembly 1, top view.
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