5z62

Electron Microscopy
3.6Å resolution

Structure of human cytochrome c oxidase

Released:
Source organism: Homo sapiens
Primary publication:
Structure of the intact 14-subunit human cytochrome c oxidase.
Cell Res 28 1026-1034 (2018)
PMID: 30030519
Related structures: EMD-6896

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetradecamer (preferred)
PDBe Complex ID:
PDB-CPX-126316 (preferred)
Entry contents:
14 distinct polypeptide molecules
Macromolecules (14 distinct):
Cytochrome c oxidase subunit 1 Chain: A
Molecule details ›
Chain: A
Length: 513 amino acids
Theoretical weight: 57.08 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00395 (Residues: 1-513; Coverage: 100%)
Gene names: COI, COXI, MT-CO1, MTCO1
Sequence domains: Cytochrome C and Quinol oxidase polypeptide I
Cytochrome c oxidase subunit 2 Chain: B
Molecule details ›
Chain: B
Length: 227 amino acids
Theoretical weight: 25.58 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00403 (Residues: 1-227; Coverage: 100%)
Gene names: COII, COX2, COXII, MT-CO2, MTCO2
Sequence domains:
Structure domains:
Cytochrome c oxidase subunit 3 Chain: C
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Chain: D
Cytochrome c oxidase subunit 5A, mitochondrial Chain: E
Cytochrome c oxidase subunit 5B, mitochondrial Chain: F
Cytochrome c oxidase subunit 6A1, mitochondrial Chain: G
Cytochrome c oxidase subunit 6B1 Chain: H
Cytochrome c oxidase subunit 6C Chain: I
Cytochrome c oxidase subunit 7A2, mitochondrial Chain: J
Cytochrome c oxidase subunit 7B, mitochondrial Chain: K
Cytochrome c oxidase subunit 7C, mitochondrial Chain: L
Cytochrome c oxidase subunit 8A, mitochondrial Chain: M
Cytochrome c oxidase subunit NDUFA4 Chain: N

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-6896