› 5z80

Solution NMR

Solution structure for the 1:1 complex of a platinum(II)-based tripod bound to a hybrid-1 human telomeric G-quadruplex

Released:
DOI: 10.2210/pdb5z80/pdb
PDB entry 5z80 coloured by chain, ensemble of 10 models, front view.
PDB entry 5z80 coloured by chain, ensemble of 10 models, side view.
PDB entry 5z80 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding.
Liu W, Zhong YF, Liu LY, Shen CT, Zeng W, Wang F, Yang D, Mao ZW
OpenAccess logo Nat Commun 9 3496 (2018)
PMID: 30158518

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-119486 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
G-quadruplex DNA (26-MER) Chain: A
Molecule details ›
Chain: A
Length: 26 nucleotides
Theoretical weight: 8.24 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand 9F0 1 x 9F0
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 47%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

6 review citations

Targeting telomerase for cancer therapy.
Guterres et al. (2020)
5 more

6 mentions without citation

Molecular Recognition of the Hybrid-Type G-Quadruplexes in Human Telomeres.
Wu et al. (2019)
5 more