› 5zb3

X-ray diffraction
3.51Å resolution

Dimeric crystal structure of ORF57 from KSHV

Released:
DOI: 10.2210/pdb5zb3/pdb
PDB entry 5zb3 coloured by chain, front view.
PDB entry 5zb3 coloured by chain, side view.
PDB entry 5zb3 coloured by chain, top view.
Source organism: Human gammaherpesvirus 8
Primary publication:
The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function.
Yuan F, Gao ZQ, Majerciak V, Bai L, Hu ML, Lin XX, Zheng ZM, Dong YH, Lan K
OpenAccess logo PLoS Pathog 14 e1007232 (2018)
PMID: 30096191

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-558020 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Post-transcriptional regulator MTA Chains: A, B
Molecule details ›
Chains: A, B
Length: 288 amino acids
Theoretical weight: 32.24 KDa
Source organism: Human gammaherpesvirus 8
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q2HR75 (Residues: 168-455; Coverage: 63%)
Gene name: ORF57
Sequence domains: Herpesvirus transcriptional regulator family

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P6422
Unit cell:
a: 167.529Å b: 167.529Å c: 227.632Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.259 0.257 0.306
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Towards Better Understanding of KSHV Life Cycle: from Transcription and Posttranscriptional Regulations to Pathogenesis.
Yan et al. (2019)
1 more

2 mentions without citation

The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function.
Yuan et al. (2018)
1 more