Function and Biology Details
Reactions catalysed:
A long-chain (S)-3-hydroxyacyl-CoA + NAD(+) = a long-chain 3-oxoacyl-CoA + NADH
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O
Myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA
(1a) [acetyl-CoA C-acyltransferase]-S-acyl-L-cyteine + acetyl-CoA = 3-oxoacyl-CoA + [acetyl-CoA C-acyltransferase]-L-cyteine
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero octamer (preferred)
Assembly name:
Trifunctional enzyme mitochondrial (preferred)
PDBe Complex ID:
PDB-CPX-154213 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Trifunctional enzyme subunit alpha, mitochondrial
Molecule details ›
Chains: A, C, E, G
Length: 763 amino acids
Theoretical weight: 83.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 763 amino acids
Theoretical weight: 83.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P40939 (Residues: 1-763; Coverage: 100%)
Sequence domains:
Trifunctional enzyme subunit beta, mitochondrial
Molecule details ›
Chains: B, D, F, H
Length: 474 amino acids
Theoretical weight: 51.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 474 amino acids
Theoretical weight: 51.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P55084 (Residues: 1-474; Coverage: 100%)
Sequence domains:
