5zyl

X-ray diffraction
1.8Å resolution

Crystal structure of CERT START domain in complex with compound E25A

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-195280 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ceramide transfer protein Chain: A
Molecule details ›
Chain: A
Length: 237 amino acids
Theoretical weight: 27.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y5P4 (Residues: 390-624; Coverage: 38%)
  • Best match: Q9Y5P4-2 (Residues: 364-598)
Gene names: CERT, CERT1, COL4A3BP, STARD11
Sequence domains: START domain
Structure domains: Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P41212
Unit cell:
a: 60.006Å b: 60.006Å c: 153.455Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.174 0.224
Expression system: Escherichia coli BL21(DE3)