› 6ah4

X-ray diffraction
3.3Å resolution

Structure of human P2X3 receptor in complex with ATP and Ca2+ ion

Released:
DOI: 10.2210/pdb6ah4/pdb
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PDB entry 6ah4 coloured by chain, front view.
PDB entry 6ah4 coloured by chain, side view.
PDB entry 6ah4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP.
Li M, Wang Y, Banerjee R, Marinelli F, Silberberg S, Faraldo-Gómez JD, Hattori M, Swartz KJ
OpenAccess logo Elife 8 (2019)
PMID: 31232692

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157462 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
P2X purinoceptor 3 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 362 amino acids
Theoretical weight: 40.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P56373 (Residues: 17-363; Coverage: 87%)
Gene name: P2RX3
Sequence domains: ATP P2X receptor

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
4 bound ligands:
Ligand ATP 3 x ATP
Ligand NAG 8 x NAG
Ligand EDO 3 x EDO
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: C2221
Unit cell:
a: 110.903Å b: 142.5Å c: 325.336Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.243 0.24 0.29
Expression system: Homo sapiens

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Citations

5 review citations

Molecular Pharmacology of P2X Receptors: Exploring Druggable Domains Revealed by Structural Biology.
Oken et al. (2022)
4 more

5 mentions without citation

New paradigms in purinergic receptor ligand discovery.
Jacobson et al. (2023)
4 more

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