› 6c45

X-ray diffraction
2.39Å resolution

Crystal structure of human inorganic pyrophosphatase in the P212121 space group

Released:
DOI: 10.2210/pdb6c45/pdb
PDB entry 6c45 coloured by chain, front view.
PDB entry 6c45 coloured by chain, side view.
PDB entry 6c45 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Niu H, Zhu J, Huang X, Du Z

Function and Biology Details

Reaction catalysed: 
Diphosphate + H(2)O = 2 phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172229 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inorganic pyrophosphatase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 289 amino acids
Theoretical weight: 32.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15181 (Residues: 1-289; Coverage: 100%)
Gene names: IOPPP, PP, PPA1
Sequence domains: Inorganic pyrophosphatase
Structure domains: Inorganic pyrophosphatase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P212121
Unit cell:
a: 50.25Å b: 136.94Å c: 216.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.193 0.251
Expression system: Escherichia coli

Quick links