› 6dc8

X-ray diffraction
1.8Å resolution

Fab/epitope complex of mouse monoclonal antibody 8B2 targeting a non-phosphorylated tau epitope.

Released:
DOI: 10.2210/pdb6dc8/pdb
PDB entry 6dc8 coloured by chain, front view.
PDB entry 6dc8 coloured by chain, side view.
PDB entry 6dc8 coloured by chain, top view.
Source organisms:
Primary publication:
Structural characterization of monoclonal antibodies targeting C-terminal Ser404 region of phosphorylated tau protein.
Chukwu JE, Congdon EE, Sigurdsson EM, Kong XP
MAbs 11 477-488 (2019)
PMID: 30794086

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-536077 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
IgG light chain Chain: L
Molecule details ›
Chain: L
Length: 218 amino acids
Theoretical weight: 24.24 KDa
Source organism: Mus musculus
IgG heavy chain Chain: H
Molecule details ›
Chain: H
Length: 217 amino acids
Theoretical weight: 23.43 KDa
Source organism: Mus musculus
Microtubule-associated protein tau Chain: P
Molecule details ›
Chain: P
Length: 31 amino acids
Theoretical weight: 3.27 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand GOL 3 x GOL
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL14-1
Spacegroup: P43212
Unit cell:
a: 68.836Å b: 68.836Å c: 198.853Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.179 0.219
Expression system: Not provided

Quick links

Citations

3 review citations

Treatment of Alzheimer's Disease and Blood-Brain Barrier Drug Delivery.
Pardridge WM. (2020)
2 more

3 mentions without citation

Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status.
Pinzi et al. (2023)
2 more