› 6dm8

X-ray diffraction
2.7Å resolution

Understanding the Species Selectivity of Myeloid cell leukemia-1 (Mcl-1) inhibitors

Released:
DOI: 10.2210/pdb6dm8/pdb
PDB entry 6dm8 coloured by chain, front view.
PDB entry 6dm8 coloured by chain, side view.
PDB entry 6dm8 coloured by chain, top view.
Source organisms:
Primary publication:
Understanding the Species Selectivity of Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors.
Zhao B, Arnold AL, Coronel MA, Lee JH, Lee T, Olejniczak ET, Fesik SW
Biochemistry 57 4952-4958 (2018)
PMID: 30011190

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142549 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Maltose/maltodextrin-binding periplasmic protein Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 518 amino acids
Theoretical weight: 57.44 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P0AEX9 (Residues: 27-392; Coverage: 99%)
  • Canonical: P97287 (Residues: 154-302; Coverage: 45%)
Gene names: JW3994, Mcl1, b4034, malE
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
1 bound ligand:
Ligand 6AK 24 x 6AK
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P1
Unit cell:
a: 76.206Å b: 104.153Å c: 146.206Å
α: 89.86° β: 89.8° γ: 89.97°
R-values:
R R work R free
0.246 0.245 0.288
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization.
McAloney et al. (2024)