› 6ean

X-ray diffraction
2.9Å resolution

CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT F488I STABILIZED IN THE PREFUSION STATE

Released:
DOI: 10.2210/pdb6ean/pdb
PDB entry 6ean coloured by chain, front view.
PDB entry 6ean coloured by chain, side view.
PDB entry 6ean coloured by chain, top view.
Source organism: Human orthopneumovirus
Entry authors: Battles MB, McLellan JS

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136982 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fusion glycoprotein F0 Chain: F
Molecule details ›
Chain: F
Length: 568 amino acids
Theoretical weight: 63.18 KDa
Source organism: Human orthopneumovirus
Expression system: Homo sapiens
UniProt:
  • Canonical: P03420 (Residues: 1-513; Coverage: 89%)
Gene name: F
Sequence domains: Fusion glycoprotein F0

Ligands and Environments

3 bound ligands:
Ligand NAG 1 x NAG
Ligand NHE 2 x NHE
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P4132
Unit cell:
a: 168.73Å b: 168.73Å c: 168.73Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.184 0.216
Expression system: Homo sapiens

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