› 6eor

X-ray diffraction
2.9Å resolution

DPP9 - 1G244

Released:
DOI: 10.2210/pdb6eor/pdb
PDB entry 6eor coloured by chain, front view.
PDB entry 6eor coloured by chain, side view.
PDB entry 6eor coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer.
Ross B, Krapp S, Augustin M, Kierfersauer R, Arciniega M, Geiss-Friedlander R, Huber R
Proc Natl Acad Sci U S A 115 E1437-E1445 (2018)
PMID: 29382749

Function and Biology Details

Reaction catalysed: 
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183164 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dipeptidyl peptidase 9 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 869 amino acids
Theoretical weight: 99.21 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q86TI2 (Residues: 1-863; Coverage: 100%)
Gene names: DPP9, DPRP2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand 9XH 4 x 9XH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 119.357Å b: 117.212Å c: 163.396Å
α: 90° β: 105.57° γ: 90°
R-values:
R R work R free
0.269 0.265 0.332
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Structures and functions of the inflammasome engine.
Wang et al. (2021)
1 more

3 mentions without citation

Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer.
Ross et al. (2018)
2 more