› 6ezl

X-ray diffraction
2.07Å resolution

Crystal structure of aspartate aminotransferase from Trypanosoma cruzi at 2.07 Angstrom resolution

Released:
DOI: 10.2210/pdb6ezl/pdb
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PDB entry 6ezl coloured by chain, front view.
PDB entry 6ezl coloured by chain, side view.
PDB entry 6ezl coloured by chain, top view.
Source organism: Trypanosoma cruzi strain CL Brener
Entry authors: Jagoe WN, Khan AR

Function and Biology Details

Reaction catalysed: 
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175455 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aspartate aminotransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 404 amino acids
Theoretical weight: 44.87 KDa
Source organism: Trypanosoma cruzi strain CL Brener
Expression system: Escherichia coli
UniProt:
  • Canonical: Q4D080 (Residues: 1-404; Coverage: 100%)
Gene name: Tc00.1047053503841.70
Sequence domains: Aminotransferase class I and II
Structure domains: Type I PLP-dependent aspartate aminotransferase-like (Major domain)

Ligands and Environments


Cofactor: Ligand PLP 2 x PLP
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: C2
Unit cell:
a: 118.495Å b: 59.086Å c: 139.015Å
α: 90° β: 112.64° γ: 90°
R-values:
R R work R free
0.181 0.18 0.229
Expression system: Escherichia coli

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