› 6ezq

X-ray diffraction
2.39Å resolution

human Serum Albumin complexed with NBD-C12 fatty acid

Released:
DOI: 10.2210/pdb6ezq/pdb
PDB entry 6ezq coloured by chain, front view.
PDB entry 6ezq coloured by chain, side view.
PDB entry 6ezq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Identification and Characterization of a Single High-Affinity Fatty Acid Binding Site in Human Serum Albumin.
Wenskowsky L, Schreuder H, Derdau V, Matter H, Volkmar J, Nazaré M, Opatz T, Petry S
Angew Chem Int Ed Engl 57 1044-1048 (2018)
PMID: 29193545

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136176 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chain: A
Molecule details ›
Chain: A
Length: 585 amino acids
Theoretical weight: 66.57 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02768 (Residues: 25-609; Coverage: 99%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

1 bound ligand:
Ligand C7K 2 x C7K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: C2
Unit cell:
a: 98.48Å b: 52.72Å c: 123.3Å
α: 90° β: 110.1° γ: 90°
R-values:
R R work R free
0.187 0.182 0.298

Quick links

Citations

1 review citation

NBD-based synthetic probes for sensing small molecules and proteins: design, sensing mechanisms and biological applications.
Jiang et al. (2021)
9 other articles

6 mentions without citation

Resolving Binding Events on the Multifunctional Human Serum Albumin.
Wenskowsky et al. (2020)
5 more