PDB 6fjt structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Reaction catalysed:

Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.

Biochemical function:

serine-type endopeptidase activity

Biological process:

blood coagulation

Cellular component:

extracellular region

Sequence domains:

1 more domain

Structure analysis Details

Assembly composition:

hetero trimer (preferred)

Assembly name:

alpha-thrombin complex and peptide (preferred)

PDBe Complex ID:

PDB-CPX-133125 (preferred)

Entry contents:

3 distinct polypeptide molecules

Macromolecules (3 distinct):

Thrombin light chain Chain: L

Molecule details ›

Chain: L
Length: 28 amino acids
Theoretical weight: 3.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

Canonical: P00734 (Residues: 333-360; Coverage: 5%)

Gene name: F2
Sequence domains: Thrombin light chain

Thrombin heavy chain Chain: H

Molecule details ›

Chain: H
Length: 251 amino acids
Theoretical weight: 28.89 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

Canonical: P00734 (Residues: 364-621; Coverage: 42%)

Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Hirudin variant-2 Chain: I

Molecule details ›

Chain: I
Length: 11 amino acids
Theoretical weight: 1.49 KDa
Source organism: Hirudo medicinalis
Expression system: Hirudo medicinalis