› 6fjx

X-ray diffraction
2.25Å resolution

Structure and function of aldehyde dehydrogenase from Thermus thermophilus: An enzyme with an evolutionarily-distinct C-terminal arm (Native protein)

Released:
DOI: 10.2210/pdb6fjx/pdb
PDB entry 6fjx coloured by chain, front view.
PDB entry 6fjx coloured by chain, side view.
PDB entry 6fjx coloured by chain, top view.
Source organism: Thermus thermophilus HB27
Primary publication:
The quaternary structure of Thermus thermophilus aldehyde dehydrogenase is stabilized by an evolutionary distinct C-terminal arm extension.
Hayes K, Noor M, Djeghader A, Armshaw P, Pembroke T, Tofail S, Soulimane T
OpenAccess logo Sci Rep 8 13327 (2018)
PMID: 30190503

Function and Biology Details

Reaction catalysed: 
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180878 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aldehyde dehydrogenase domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 530 amino acids
Theoretical weight: 58.62 KDa
Source organism: Thermus thermophilus HB27
UniProt:
  • Canonical: Q72KD3 (Residues: 1-530; Coverage: 100%)
Gene name: TT_C0513
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand PGE 1 x PGE
Ligand BOG 2 x BOG
Ligand SO4 6 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P41212
Unit cell:
a: 105.29Å b: 105.29Å c: 314.45Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.189 0.21

Quick links

Citations

7 citation in other articles

Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3.
Castellví et al. (2022)
6 more

4 mentions without citation

Insights into Aldehyde Dehydrogenase Enzymes: A Structural Perspective.
Shortall et al. (2021)
3 more