› 6flh

X-ray diffraction
1.79Å resolution

Monomeric Human Cu,Zn Superoxide dismutase, SOD1 7+7, apo form

Released:
DOI: 10.2210/pdb6flh/pdb
PDB entry 6flh coloured by chain, front view.
PDB entry 6flh coloured by chain, side view.
PDB entry 6flh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The Cost of Long Catalytic Loops in Folding and Stability of the ALS-Associated Protein SOD1.
Yang F, Wang H, Logan DT, Mu X, Danielsson J, Oliveberg M
J Am Chem Soc 140 16570-16579 (2018)
PMID: 30359015

Function and Biology Details

Reaction catalysed: 
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132490 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Superoxide dismutase [Cu-Zn] Chain: A
Molecule details ›
Chain: A
Length: 118 amino acids
Theoretical weight: 11.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P00441 (Residues: 2-154; Coverage: 77%)
Gene name: SOD1
Sequence domains: Copper/zinc superoxide dismutase (SODC)

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)
Spacegroup: R32
Unit cell:
a: 83.214Å b: 83.214Å c: 133.478Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.171 0.17 0.197
Expression system: Escherichia coli K-12

Quick links

Citations

1 review citation

SOD1 in ALS: Taking Stock in Pathogenic Mechanisms and the Role of Glial and Muscle Cells.
Peggion et al. (2022)
4 other articles

2 mentions without citation

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.
Nguyen et al. (2021)
1 more