› 6frj

X-ray diffraction
1.4Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-211748 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
scFv-SM3 Chain: H
Molecule details ›
Chain: H
Length: 244 amino acids
Theoretical weight: 25.76 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
Structure domains: Immunoglobulins
APD-SeThr-RP Chain: B
Molecule details ›
Chain: B
Length: 7 amino acids
Theoretical weight: 718 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand EDO 4 x EDO
Ligand A2G 1 x A2G
1 modified residue:
Ligand T9E 1 x T9E

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P212121
Unit cell:
a: 35.353Å b: 68.612Å c: 90.609Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.205 0.23
Expression systems:
  • Komagataella pastoris
  • Not provided

Quick links

Citations

7 review citations

Tumor-associated O-glycans of MUC1: Carriers of the glyco-code and targets for cancer vaccine design.
Beckwith et al. (2020)
6 more

1 mention without citation

Molecular Recognition of GalNAc in Mucin-Type O-Glycosylation.
Sanz-Martinez et al. (2023)