› 6fxw

X-ray diffraction
1.57Å resolution

Structure of Leishmania infantum type B ribose 5-phosphate isomerase

Released:
DOI: 10.2210/pdb6fxw/pdb
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PDB entry 6fxw coloured by chain, front view.
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PDB entry 6fxw coloured by chain, top view.
Source organism: Leishmania infantum
Primary publication:
Toward Chemical Validation of Leishmania infantum Ribose 5-Phosphate Isomerase as a Drug Target.
Dickie EA, Ronin C, Sá M, Ciesielski F, Trouche N, Tavares J, Santarem N, Major LL, Pemberton IK, MacDougall J, Smith TK, Cordeiro-da-Silva A, Ciapetti P
Antimicrob Agents Chemother 65 e0189220 (2021)
PMID: 33875438

Function and Biology Details

Reaction catalysed: 
D-ribose 5-phosphate = D-ribulose 5-phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107324 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Putative ribose 5-phosphate isomerase Chain: A
Molecule details ›
Chain: A
Length: 175 amino acids
Theoretical weight: 18.97 KDa
Source organism: Leishmania infantum
Expression system: Escherichia coli
UniProt:
  • Canonical: A4I3S4 (Residues: 1-172; Coverage: 100%)
Gene name: LINJ_28_2100
Sequence domains: Ribose/Galactose Isomerase
Structure domains: Sugar-phosphate isomerase, RpiB/LacA/LacB

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: F222
Unit cell:
a: 80.92Å b: 83.65Å c: 89.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.146 0.144 0.178
Expression system: Escherichia coli

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Citations

2 citation in other articles

Characterization of a novel ribose-5-phosphate isomerase B from Curtobacterium flaccumfaciens ZXL1 for D-allose production.
Zheng et al. (2024)
1 more

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