› 6gbi

X-ray diffraction
1.25Å resolution

Wnt signalling

Released:
DOI: 10.2210/pdb6gbi/pdb
PDB entry 6gbi coloured by chain, front view.
PDB entry 6gbi coloured by chain, side view.
PDB entry 6gbi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the Wnt signaling enhancer LYPD6 and its interactions with the Wnt coreceptor LRP6.
Zhao Y, Ren J, Lu W, Harlos K, Jones EY
FEBS Lett 592 3152-3162 (2018)
PMID: 30069874

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183262 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ly6/PLAUR domain-containing protein 6 Chain: A
Molecule details ›
Chain: A
Length: 104 amino acids
Theoretical weight: 11.71 KDa
Source organism: Homo sapiens
Expression system: Mammalian expression vector pCI-NEO-FLAG-SMNdelta3,4,5,6,7

Ligands and Environments

3 bound ligands:
Ligand NAG 1 x NAG
Ligand GOL 2 x GOL
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P41212
Unit cell:
a: 61.98Å b: 61.98Å c: 68.55Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.162 0.162 0.165
Expression system: Mammalian expression vector pCI-NEO-FLAG-SMNdelta3,4,5,6,7

Quick links

Citations

2 review citations

Lynx Prototoxins: Roles of Endogenous Mammalian Neurotoxin-Like Proteins in Modulating Nicotinic Acetylcholine Receptor Function to Influence Complex Biological Processes.
Miwa et al. (2019)
1 more

1 mention without citation

Evolution and Medical Significance of LU Domain-Containing Proteins.
Leth et al. (2019)